Advantage II - Kitten
For Kittens under 5 lb
Advantage II - Small Cat
For Cats 5-9 lb
Advantage II - Large Cat
For Cats over 9 lb

Advantage Flea Products for You Home and Yard

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Nupro Nutritional Supplements for Cats
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Need Advantage II for Dogs?

Advantage II Cat
​Frequently Asked Questions

I have never had a flea problem before. Where are my pets picking up fleas?
Fleas are very hardy pests that are quite capable of hitching rides on a variety of mammals. Wild animals or feral pets traveling through the environment may be a source for a pet’s exposure.
Fleas may be brought to the house by:
  • You – attached to clothing, luggage, dog blankets, etc.
  • Your pet – any time your pet steps outside your house, they are potentially exposed to fleas, especially in areas where there are other animals.
  • Stray or homeless cats and dogs – since these animals are not being cared for, they are easy targets for fleas. A single feral cat walking through your back yard even just one time may drop many flea eggs into the grass or under shrubs.
  • Wildlife – particularly raccoons and opossums. These animals typically aren’t seen very often, because they are active at night. A single opossum can carry as many as 1,000 adult fleas! An opossum walking through your back yard even just one time can drop many flea eggs into the grass or under shrubs as they pass through.
  • Non-treated pets in the household – most dogs are treated for fleas and ticks. Often, the cats in the household are not, especially if they are indoor only cats.  
  • Non-treated pets in the neighborhood – you may be vigilant about treating your pets for fleas, but your neighbor(s) may not. 
 
When using Advantage® II, what type of shampoo should I use?
We suggest using non-stripping shampoos that are specifically designed for use on pets. Non-stripping shampoos are generally soap-free formulations designed for general cleansing. We make a variety of shampoos that are non-stripping, general cleansing shampoos.
We do NOT recommend the use of either medicated shampoos (commonly used as treatment of various skin conditions). We also do NOT recommend the use of shampoos used for humans.

When can I bathe my pet after applying Advantage® II?
We recommend bathing BEFORE applying product. The product can be applied once the pet is towel dried. If a bath is necessary between applications, we recommend waiting at least 4 days after applying the product. Please use a non-stripping, pet shampoo.
How often can I bathe my pet when using Advantage® II?
We recommend bathing your pet not more than once monthly when using topical products. More frequent bathing may reduce the duration of efficacy.
We recommend bathing BEFORE applying monthly product. The product can be applied once the pet is towel dried.
We suggest using non-stripping shampoos that are specifically designed for use on pets. Non-stripping shampoos are generally soap free formulations designed for general cleansing. Bayer makes a variety of shampoos that are non-stripping, general cleansing shampoos.

How long after bathing my pet do I need to wait to apply Advantage® II?
Apply Advantage® II after your pet has been towel dried.
 
How often can I allow my pet to swim when using Advantage® II?
We recommend letting your pet swim no more than once a month.

Can I apply Advantage® II for dogs on my cats?
No. Follow label directions for the application of our flea products.
If the label directions fail to answer your questions, please consult your pet’s veterinarian.

Can I apply Advantage® II for cats on my dogs?
No. Follow label directions for the application of our flea products.
If the label directions fail to answer your questions, please consult your pet’s veterinarian.

Can I split tubes of Advantage® II between my cats?
No. Follow label directions for the application of Advantage® II. If the label directions fail to answer your questions, please consult your pet’s veterinarian.

Can I use Advantage® II on my bunnies?
No. Follow label directions for the application of our products.
If the label directions fail to answer your questions, please consult your pet’s veterinarian.

Can I use Advantage® II if my pet is on medication?
Please consult your pet’s veterinarian to discuss appropriate products to use in conjunction with any other medications your pet may be taking.

How do I store and dispose of Advantage® II?
Do not contaminate water, food or feed by storage or disposal.
Storage: Store in a cool, dry place. Protect from Freezing. Keep out of reach of children.
Disposal and Container Handling: NonrefIIlable container. If empty: Do not reuse this container. Place in trash or offer for recycling if available. If partly filled: Call your local solid waste agency for disposal instructions. Never place unused product down any indoor or outdoor drain.

What are the benefits of Advantage® II for cats?
Here are the benefits you can expect from Advantage® II for cats:
  • Kills through contact so fleas don't have to bite to die
  • Kills all flea life stages
  • Topical application
  • Kills reinfesting fleas within 2 hours, i.e., fleas jumping on the pet 12 hours after product administration
  • Waterproof — recommend use of a soap-free shampoo
 
How does Advantage® II work?
Advantage® II combines two active ingredients:
  • Imidacloprid attacks the flea's nervous system – paralyzing and ultimately killing it.
  • Pyriproxyfen is an insect growth regulator (IGR) that kills flea eggs and larvae.

This combination plays a crucial role in existing infestations, because:
In an existing infestation you might only be aware of the adult fleas, which only represent around 5% of the full infestation and are found on the pet.
Immature flea life stages (flea eggs, larvae and pupae) which live in the pet’s environment consist of around 95% of the infestation and can be almost invisible to the naked eye.
 
What is the difference between Advantage® II and oral flea products?
Advantage® II flea prevention is applied to your pet topically and kills fleas through contact with the product on your pet’s skin, so fleas don't have to bite to die. With oral flea medications, fleas have to bite the pet and be exposed to the medication in the pet before the fleas are killed.

How long does Advantage® II last?
A single application of Advantage® II stops biting fleas up to one month.
How often should I use Advantage® II?
Use monthly, year-round to help keep your pet protected from fleas.

My pet is strictly indoors. Should I still use Advantage® II?
Yes. Fleas can be brought into the home by you or other pets without even realizing it. Immature flea stages remain dormant until conditions are appropriate for development and infest pets after hatching. That’s why it is important to also treat indoor pets.

I only see fleas on one of my pets. Is it sufficient to just treat the infested pet?
No. All pets in the home should be treated, since the infested pet is likely to pass on fleas to other pets it is in contact with in the same environment.

At what age can I start using Advantage® II on my cat?
Advantage® II for cats is for use on cats and kittens 8 weeks of age and older.

How do I apply Advantage® II for cats?
Applying Advantage® II flea control to your feline friend is simple and convenient. Advantage® II is available in three different weight bands for cats and kittens 8 weeks and older that weigh at least 2 pounds.
Kitten (2-5 lb)
Small Cat (5-9 lb)
Large Cat (over 9 lb)
See Advantage II application video and instructions
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What is the expiration date for Advantage® II for cats?
There is no expiration date required on the packaging by the EPA for this product. The product should be kept in its original packaging and stored as directed on the label.

How long after using another topical product do I need to wait before applying Advantage® II?
We at Bayer have not studied the concurrent use of the wide variety of other products on the market. Please consult your pet’s veterinarian for their recommendation.

How long after using Advantage® II do I need to wait before applying a different Bayer topical product?
Please consult your pet’s veterinarian for their recommendation.